Originalarbeiten  


1
Koch-Nolte F, Klein J, Hollmann C, Kühl M, Haag F, Gaskins HR, Leiter E, Thiele HG (1995) Defects in the structure and expression of the genes for the T cell marker Rt6 in NZW and (NZBxNZW)F1 mice. Int Immunol 7:883-890  
2 Klein J, Fasshauer M, Ito M, Lowell BB, Benito M, Kahn CR (1999) b3-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J Biol Chem 274:34795-34802  
3 Fasshauer M, Klein J (gleichberechtigter Erstautor), Ueki K, Kriauciunas KM, Benito M, White MF, Kahn CR (2000) Essential role of insulin receptor substrate 2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipcoytes. J Biol Chem 275:25494-501  
4 Klein J, Fasshauer M, Benito M, Kahn CR (2000) Insulin and the b3-adrenoceptor differentially regulate uncoupling protein-1 expression. Mol Endocrinol 14:764-773  
5 Schütt M, Meier M, Meyer M, Klein J, Aries SP, Klein HH (2000) The HIV-1 protease inhibitor indinavir impairs insulin signalling in HepG2 hepatoma cells. Diabetologia 43:1145-48
6 Klein J, Kern W, Fehm HL (2001) Fatigue and hyponatremia in a 75-year-old woman: unusual presentation of hypophysitis. Exp Clin Endocrinol Diabetes 109:120-123  
7 Fasshauer M, Klein J (gleichberechtigter Erstautor), Kriauciunas KM, Ueki K, Benito M, Kahn CR (2001) Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes. Mol Cell Biol (2001) 21:319-329  
8 Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R (2001) Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytes. FEBS Lett 500:60-63  
9 Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R (2001) Adiponectin gene expression is inhibited by b-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Lett 507:142-146  
10 Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R (2001) Tumor Necrosis Factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes. Biochem Biophys Res Commun 288:1027-1031  
11 Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R (2002) Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun 290:1084-1089  
12 Jost P, Fasshauer M, Jost M, Ott V, Klein HH, Klein J (2002) Atypical b-adrenergic effects on insulin signaling and action in b3-adrenoceptor-deficient brown adipocytes. Am J Physiol Endocrinol Metab 283:E146-153)  
13 Ott V, Fasshauer M, Dalski A, Klein HH, Klein J (2002) Direct effects of ciliary neurotrophic factor on brown adipocytes: evidence for a role in peripheral regulation of energy homeostasis. J Endocrinol 173:R1-8  
14 Klein J, Ott V, Schütt M, Fehm HL, Klein HH (2002) Recurrent hypoglycaemia in a patient with type 2 diabetes under fibrate therapy. J Diabetes Complicat 16:246-248  
15 Fasshauer M, Klein J, Lossner U, Paschke R (2002) Negative regulation of adipose expressed galectin-12 by isoproterenol, TNFa, insulin, and dexamethasone. Eur J Endocrinol 147:553-559  
16 Kraus D, Fasshauer M, Ott V, Meier B, Jost M, Klein HH, Klein J (2002) Leptin secretion and negative autocrine crosstalk with insulin in brown adipocytes. J Endocrinol 175:185-191
17 Ott V, Dalski A, Fasshauer M, Meier B, Kraus D, Klein HH, Tschöp M, Klein J (2002) Ghrelin and adipose tissue: direct differential effects on energy metabolism. Horm Metab Res 34:640-645
18 Fasshauer M, Klein J, Lossner U, Kratzsch J, Paschke R (2002) Isoproterenol is a positive regulator of SOCS-3 gene expression in 3T3-L1 adipocytes. J Endocrinol 175:727-733
19 Fasshauer M, Kralisch S, Klierl M, Lossner U, Bluher M, Klein J, Paschke R (2003) Adiponectin Gene Expression and Secretion is inhibited by Interleukin-6 in 3T3-L1 Adipocytes. Biochem Biophys Res Commun 301:1045-50  
20 Arribas M, Valverde AM, Burks D, Klein J, Farese RV, White MF, Benito M (2003) Essential role of protein kinase C ζ in the impairment of insulin- induced glucose transport in IRS-2-deficient brown adipocytes. FEBS letters 536:161-166  
21 Fasshauer M, Klein J, Krahlisch S, Lossner U, Kleir M, Paschke R (2003) Growth hormone is a positive regulator of Tumor Necrosis Factor a-induced adipose related protein in 3T3-L1 Adipocytes. J Endocrinol 178:523-531  
22 Fasshauer M, Klein J, Lossner U, Paschke R (2003) Suppression of Aquaporin Adipose Gene Expression by Isoproterenol, TNFa, and Dexamethasone. Horm Metab Res 35:222-227  
23 Fasshauer M, Klein J, Lossner U, Paschke R (2003) Interleukin (IL)-6 mRNA Expression is Stimulated by Insulin, Isoproterenol, Tumour Necrosis Factor Alpha, Growth Hormone, and IL-6 in 3T3-L1 Adipocytes. Horm Metab Res 35:147-152  
24 Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR (2003) Positive and negative roles of p85alpha and p85beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J Biol Chem 278:48453-48466  
25 Ott V, Fasshauer M, Meier B, Dalski A, Kraus D, Perwitz N, Klein J (2004) Ciliary neurotrophic factor directly influences endocrine adipocyte function: Inhibition of leptin via phosphatidylinositol 3-kinase in brown adipocytes. Mol Cell Endocrinol 224:21-27  
26 Klein J, Westphal S, Kraus D, Meier B, Perwitz N, Ott V, Fasshauer M, Klein HH (2004) Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes. J Endocrinol 183:299-307  
27 Fasshauer M, Krahlisch S, Klier M, Lossner U, Bluher M, Klein J, Paschke R (2004) Insulin resistance-inducing cytokines differentially regulate SOCS mRNA expression via growth factor- and Jak/Stat-signaling pathways in 3T3-L1 adipocytes. J Endocrinol 181:129-38  
28 Fasshauer M, Klein J, Krahlisch S, Klier M, Lossner U, Bluher M, Paschke R (2004) Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes. FEBS Lett 558:27-32  
29 Fasshauer M, Krahisch S, Klier M, Lössner U, Blüher M, Klein J, Chambaut-Guérin AM, Paschke R (2004) Interleukin-6 is a positive regulator of tumor necrosis factor alpha-induced adipose-related protein in 3T3-L1 adipocytes. FEBS Lett 560:153-7  
30 Fasshauer M, Klein J, Kralisch S, Klier M, Lossner U, Bluher M, Paschke R (2004)  Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 317:598-604  
31 Fasshauer M, Klein J, Kralisch S, Klier M, Lossner U, Bluher M, Paschke R (2004) Serum amyloid A3 expression is stimulated by dexamethasone and interleukin-6 in 3T3-L1 adipocytes. J Endocrinol 183:561-7  
32 Jost M, Jost P, Klein J, Klein HH (2005) The b3-adrenergic agonist CL316,243 inhibits insulin signaling but not glucose uptake in primary human adipocytes. Exp Clin Endocrinol Diabetes 113:418-22  
33 Kraus D, Jager J, Meier B, Fasshauer M, Klein J (2005) Aldosterone inhibits thermogenesis, induces insulin resistance, and stimulates inflammatory adipokines in adipocytes. Horm Metab Res 37:455-459  
34 Kralisch S, Klein J, Lossner U, Bluher M, Paschke R, Stumvoll M, Fasshauer M (2005) Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes. J Endocrinol 185:R1-8  
35 Kralisch S, Klein J, Lossner U, Bluher M, Paschke R, Stumvoll M, Fasshauer M (2005) Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 289:E586-E590  
36 Perwitz N, Sievert H, Meier B, Drenckhan M, Fasshauer M, Klein J (2005) Cocaine- and Amphetamine-Related Transcript (CART) directly stimulates UCP-1 expression and enhances insulin-induced glucose uptake. Adipocytes 1:145-150  
37 Kralisch S, Klein J, Lossner U, Bluher M, Paschke R, Stumvoll M, Fasshauer M (2005) Proinflammatory adipocytokines induces TIMP-1 expression in 3T3-L1 adipocytes. FEBS letters 579:6417-22  
38 Kralisch S, Klein J, Lossner U, Bluher M, Paschke R, Stumvoll M, Fasshauer M (2005) Isoproterenol, TNFa, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes. Mol Cell Endocrinol  240:43-9  
39 Kralisch S, Klein J, Lossner U, Bluher M, Paschke R, Stumvoll, Fasshauer M (2006) Isoproterenol stimulates Monocyte Chemoattractant Protein-1 Expression in 3T3-L1 Adipocytes.  Regul Pept 135:12-6  
40 Perwitz N, Fasshauer M, Klein J (2006) Cannabinoid receptor signaling directly inhibits thermogenesis and alters expression of adiponectin and visfatin. Horm Metab Res 38:356-8  
41 Klein J, Fehm HL (2005) Letter to the Editor: Unusual presentation of hypophysitis preceding an empty sella in a 75-year-old woman. Neuro Endocrinol Lett 26:757-8  
42 Kralisch S, Klein J, Lossner U, Bluher M, Paschke R, Stumvoll M, Fasshauer M (2006) Plasminogen activator inhibitor-1 expression and secretion are stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes. Mol Cell Endocrinol 253:56-62  
43
 Mäuser W, Perwitz N, Meier B, Fasshauer M, Klein J (2007) Direct Adipotropic Actions of Atorvastatin: Differentiation State-Dependent Induction of Apoptosis, Modulation of Endocrine Function, and Inhibition of Glucose Uptake. Eur J Pharmacol 564:37-46
44 Westphal S, Perwitz N, Iwen KAH, Kraus D, Schick R, Fasshauer M, Klein J (2007) Expression of ATRAP in adipocytes and negative regulation by beta3-adrenergic stimulation of JAK/STAT. Horm Metab Res 40:165-171
45 Iwen KAH, Senyaman Ö, Schwartz A, Drenckhan M, Meier B, Perwitz N, Hadaschik D, Klein J (2008) Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a pro-inflammatory adipokine profile, and stimulates UCP-1 in adipocytes. J Endocrinol 196:465-472
46 Iwen KAH, Pais I, Klein J, Lehnert H (2009) 40-year-old patient with newly diagnosed diabetes mellitus and progressive migraine attacks. Dtsch Med Wochenschr 134:307-308
47 Kovsan J, Osnis A, Maissel A, Mazor L, Tarnovscki T, Hollander L, Ovadia S, Meier B, Klein J, Bashan N, Rudich A (2009) Depot-specific adipocyte cell lines reveal differential drug-induced responses of white adipocytes - relevance for partial lipodystrophy. Am J Physiol Endocrinol Metab 296:E315-322
48 Zhang Y, Huypens P, Adamson AW, Chang JS, Henaganl TM, Lenardl NR, Burk D, Klein J, Perwitz N, Shin J, Fasshauer M, Kralli A, Gettys TW (2009) Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha. J Biol Chem 284:32813-26
49 Perwitz N, Wenzel J, Wagner I, Büning J, Drenckhan M, Zarse K, Ristow M, Lilienthal W, Lehnert H, Klein J (2009) Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes. Diabetes Obes Metab 12:158-66
50 Hoppmann J, Perwitz N, Meier B, Fasshauer M, Hadaschik D, Lehnert H, Klein J (2010) The balance between gluco- and mineralo-corticoid action critically determines inflammatory adipocyte responses. J Endocrinol 204:153-64
51 Küchler S, Perwitz N, Schick RR, Klein J, Westphal S (2010) Arginine-Vasopressin directly promotes a thermogenic and pro-inflammatory adipokine expression profile in brown adipocytes. Regul Pept 164:126-32
52 Iwen KA, Wenzel ET, Ott V, Perwitz N, Wellhöner P, Lehnert H, Dodt C, Klein J (2011) Cold-Induced Alteration of Adipokine Profile in Humans. Metabolism 60:430-7
53 Wagner I, Perwitz N, Drenckhan M, Lehnert H, Klein J (2011) Cannabinoid Type 1 Receptor mediates Depot-Specific Effects on Differentiation, Inflammation and Oxidative Metabolism in Inguinal and Epididymal White Adipocytes. Nutrition and Diabetes 1, e16; doi:10.1038/nutd.2011.12
Übersichten  

54
Klein J, Fasshauer M, Klein HH, Benito M, Kahn CR (2002) Novel adipocyte lines from brown fat: A model system for the study of differentiation, energy metabolism, and insulin action. Bioessays 24:382-388  
55 Perwitz N, Fasshauer M, Klein J (2004) Die neue Sicht des Fettgewebes: „Mastermind“ hinter Pathogenese und Therapie des Metabolischen Syndroms. Focus (Universität zu Lübeck) 21:14-21  
56 Perwitz N, Klein J (2004) Neue Konzepte gegen das Metabolische Syndrom. Medical Tribune 36:10  
57 Fasshauer M, Klein J, Bluher M, Paschke R (2004) Adipokine: Mögliches Bindeglied zwischen Insulinresistenz und Adipositas. Deutsches Ärzteblatt 101: A3491-95  
58 Kraus D, Fasshauer M, Klein J (2005) Neuropeptide and peripheral hormone crosstalk with adipocyte function. Adipocytes 1:95-120  
59 Kralisch S, Klein J, Bluher M, Paschke R, Stummvoll M, Fasshauer M (2005) Therapeutic perspectives of adipocytokines. Expert Opin Pharmacother 6:863-72  
60 Klein J, Perwitz N, Kraus D, Blüher M, Fasshauer M (2006) Adipose tissue as source and target for novel therapies. Trends Endocrinol Metab 17:26-32  
61 Iwen KAH, Perwitz N, Kraus D, Fasshauer M, Klein J (2006) Putting fat cells onto the road map to novel therapeutic strategies. Discovery Medicine 6:75-81  
62 Klein J, Fasshauer M (2007) What are subcutaneous adipocytes really good for? Exp Dermatol 16:45-70
63 Iwen KAH, Klein J (2008) Therapiemöglichkeiten der Adipositas. Die Medizinische Welt 1-2:18-22
64 Iwen KA, Perwitz N, Lehnert H, Klein J (2011) Overweight: A valid
predictor of cardiometabolic risk? Internist 52:354-6

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